I watched a bit of this a while ago (I think the first three episodes) and I thought it was pretty good.
I really like the kind of manic style of comedy, especially the very offbeat kind and
Excel Saga really had that. The animation seemed decent enough as well - sort of that kind of 'generic' anime style.
The show sort of reminds me of
FLCL although I can't say for sure because I haven't seen past a little bit of
Excel. I feel bad for the main character's poor dog though. As far as I can remember she was always trying to eat it.